The Global HIV Vaccine Enterprise (the Enterprise) is a unique alliance of independent organizations around the world dedicated to accelerating the development of a preventive HIV vaccine. The Enterprise, composed of top research, funding, advocacy and other stakeholder organizations, develops and drives implementation of the Scientific Strategic Plan for HIV vaccine development. Enterprise stakeholders set shared research agendas, create new structures for information sharing, develop new tools to harmonize global research efforts, and bring new organizations, expertise and resources to the challenge.