The mission of Millennium Promise is to advance sustainable development in communities across Sub-Saharan Africa using innovative solutions and scalable systems aimed at achieving the Sustainable Development Goals (SDGs) including the end of extreme poverty. From 2005-15, Millennium Promise provided the operational platform and resource mobilization for the Millennium Villages Project which deployed a holistic, science-based approach to accelerate progress on the Millennium Development Goals for more than 500,000 people across sub-Saharan Africa. Today we build on this work to implement the SDGs at the sub-national level through several initiatives, including the Sustainable Districts Program, Connect To Learn, the Lead Farmer Program, and the One Million Community Health Workers Campaign.