iRIS, by iMedRIS Data Corporation, is world-class software for pre-clinical and clinical trials, integrating trial functions into an easy to use Web-based application. iRIS modules configure to the specific needs of institutions, creating client-focused programs that eliminate redundancy of data input while maximizing the productivity of trials and reporting. Essentially, iRIS is a suite of tools that assists with the management of time-consuming regulatory requirements. Significantly with iRIS, researchers find that their focus is not on managing essential reporting issues, formerly performed all in hard copy, but on their studies and subjects. Clients receive the most control of any system available, along with both Web-based and onsite training. For over a decade, iMedRIS, based in Southern California, has provided research facilities and institutions with a variety of iRIS modules. Backed by a dedicated team of developers, project managers, and customer support representatives, iMedRIS remains the conscientious forerunner of medical research software design and implementation. All current trends point to completely paperless clinical trial reporting with more research institutions realizing the need for electronic recording methods. The mission at iMedRIS is to provide each client with an integrated management tool with several options to better support each institution’s configuration requirements and needs. With the knowledge and support of the development team and management staff, iMedRIS strives to ensure each client is given the appropriate instruments for a seamless transition to a completely paperless research environment.