The Uppsala Branch is localized at the Biomedical Center in Uppsala and operates under a contract with Uppsala University and the University Hospital. The Branch in Uppsala was established in 1986. The aim of our research is to elucidate the signaling pathways that control cell growth. We study factors which stimulate or inhibit cell growth and try to elucidate the molecular mechanism whereby such factors exert their effects on cells. The uncontrolled growth of cancer cells is to some extent due to constitutive activation of pathways that in the normal cell are controlled by growth stimulatory factors or loss of components of growth inhibitory pathways. A goal is to develop clinically useful antagonists of growth factor action