The mission of the Irving Institute for Clinical and Translational Research is to advance discoveries, knowledge, and innovation to improve human health across the lifespan for diverse populations in upper Manhattan and around the world. By mobilizing and connecting Columbia University’s researchers, we aim to create a seamless integration of community, academic partnerships and improved healthcare for all. Our commitment to train a multi-faceted workforce, provide vital resources to researchers, and improve the efficiency of research processes, promotes the collaborative team science framework needed to translate research discoveries into effective interventions that address current and future health concerns. The Irving Institute has two locations – a headquarters located at the Columbia University Irving Medical Center and an off-campus center, the Columbia Community Partnership for Health located 10 blocks north at 390 Fort Washington Avenue. The institute provides over 60 services and programs to Columbia University researchers and study teams, our community partners in upper Manhattan, and collaborators from other academic institutions, industry, and local and regional government. These offerings span all stages of the translational science spectrum from basic research to public health, and cover six broad categories including research support services, core facilities, funding opportunities, community engagement, seminars and workshops, and education, training and mentoring. The Irving Institute’s main partners are NewYork-Presbyterian Hospital and the New York State Psychiatric Institute.