Leveraging innovation and technology is essential to fast-track progress to reach Universal Health Coverage (UHC) and other health-related Sustainable Development Goal (SDG) targets. While new solutions for health are emerging in different parts of the world, these do not always get adopted on scale to deliver impact. There is a disconnect between innovators and implementers that needs to be bridged. The Health Innovation Exchange identifies challenges faced by implementers and connects them with innovations that have high potential for impact. It also links with investors to scale up the efforts and develop sustainable solutions. The Health Innovation Exchange builds upon and shares the expertise of countries, global health actors, innovators, communities and the private sector. Launched on the sidelines of the World Health Assembly in Geneva in May 2019, the HIEx is a UNAIDS initiative. UNAIDS is the Joint United Nations Programme on HIV/AIDS (UNAIDS) leads and inspires the world to achieve its shared vision of zero new HIV infections, zero discrimination and zero AIDS-related deaths. The Health Innovation Exchange is founded on a shared commitment to leave no one behind in our journey to achieve the SDGs.