The Professional Development Hub (pd|hub) is a multi-stakeholder initiative to advance the career and professional development of scientists. Sustainability of the research enterprise is dependent on preparing PhD-level scientists adept in a host of professional skills, to ensure that our scientific workforce is ready to tackle the complex societal challenges of the 21st century. The goals of this initiative are to disseminate career and professional development approaches in ways that support adaptation, implementation, and innovation in the community; build capacity for research and evaluation to enhance the evidence basis for career and professional development (CPD) approaches; connect stakeholders across diverse networks to leverage expertise and support coordinated action to advance graduate and postdoctoral education; and advocate for career and professional development to amplify the impact of ongoing efforts and accelerate change.