Labskin’s Fibrin Gel matrix is the only commercially available laboratory-grown full thickness human skin test platform that creates new collagen production and shows the impact on your skin’s microflora balance of cosmetic and skin care products. Specifically developed to host harmful skin bacteria which allows the introduction of toxins, bacteria, viruses, and other foreign substances that trigger an immune response. Complexity: • Dermis and Epidermis; comprising o Primary human fibroblasts; and, o Primary human keratinocytes • Ability to show the impact on skin microflora • Efficacy against a range of pathogenic bacteria This allows testing for: • Cosmetic ingredients and formulation testing • Skin irritation – Sensitisation • Anti-Aging (protective ability against dehydration, pollution etc) • UV protective tests • Microflora protection • Anti Microbial (skin conditions – psoriasis, eczema, etc.) • Anti Fungal – Anti Dandruff • Skin barrier protection • Pre/Pro-biotics (ingredient testing in and out of formulation) • Immune response (natural skin protective abilities) • Drug delivery • Wound healing • Anti-microbial wound dressing • Gene expression, Lipidomics, and Metabolomics Service offerings: 1. Quantify collagen production; 2. Quantify Elastin and Filaggrin to confirm changes in the amount of protein 3. Quantify total Collagen in tissue; and, 4. Provide indications on the amount of Hyaluronic Acid; 5. Provide data on AQP3; and, 6. Provide Gene Expression; Product Claims Package: 1. Bronze: a. Confirmation of markers showing the beneficial effect of the product on the microflora of the skin b. Maintains the balance of your Skin Microflora i. Healthier looking skin ii. Better looking skin 2. Silver: a. Anti-aging effects i. Younger looking skin b. Ability to maintain/enhance a balanced microflora c. Confirmation of markers showing the beneficial effect of the product on the microflora of the skin d. Maintains the balance of your Skin Microflora. i. Healthier looking skin ii. Better looking skin 3. Gold a. Gene expression i. Proof beyond pro-collagen production ii. Investigation and quantifiable confirmation of multiple anti-aging markers b. Anti-aging effects i. Younger looking skin c. Ability to maintain/enhance a balanced microflora d. Confirmation of markers showing the beneficial effect of the product on the microflora of the skin e. Maintains the balance of your Skin Microflora. i. Healthier looking skin ii. Better looking skin Labskin Services Key Benefits: • Contract microbiology skin-science laboratories • Independent test protocols • Third-party validation of results • Provides better response representation than standard laboratory tests • Improves decision-making outcomes • Minimises product development attrition rates • Flexible & tailored solution