DIGICORE promotes and equips cancer centres in their use of routine electronic health records (EHR) and molecular diagnostic information (MDX) for trial automation, real world outcomes research, digital diagnostics and care quality management. The ultimate goal is to shape a digital research infrastructure based on digital interoperability between its Members. Network membership supports them to improve data quality and completeness, develop new data sources and tools, share digital best practices and promote novel, digitally enabled research methods. DIGICORE is set-up as a European Economic Interest Grouping including several prominent cancer centres, two cancer networks, UNICANCER and Alleanza Contro il Cancro, and two commercial partners allied in this challenge.