Mind the Byte is a bioinformatics company that develops and provides software for computational drug discovery using Big Data and Machine Learning (AI) approaches. We work with partners on a consultancy basis or offer an easy to use Software as a Service (SaaS) package to allow clients to apply the High-performance computing platform on a flexible pay-per-use basis without investment in hardware or software licenses. Mind the Byte has developed a versatile set of applications using cloud computing which lowers the entry barrier to the technology, e.g. i) virtual profiling methods to facilitate the identification of targets and mechanisms of action of phenotypic screening hits or natural products with reported activity ii) virtual screening methods to identify compounds acting on a specific target by mining internal or commercial compound libraries, to expand hit or lead series and to conduct repurposing of known drugs. iii) MtBDock - a fully integrated docking protocol reducing the amount of false positives by incorporation of all prosthetic groups and conformational minimization iv) SmartDock - an experimentally validated docking protocol with further improved performance based on machine learning of PDB target-ligand interactions Mind the Byte is an Amazon Web Services technology partner - a seal of quality that has only been awarded to five companies in this sector – to ensure security and reliability. The company was founded in 2011 by Alfons Nonell-Canals, a specialist in computer-aided drug design and in large-scale chemical and biological analyses, and has since expanded with an experienced staff.