Diagonal Therapeutics Inc. is a stealth-stage biotechnology company using antibodies to activate complex receptors in rare diseases, oncology, and immunology/autoimmune diseases. We combine state-of-art immune repertoire mining, computational design, and protein engineering techniques to craft drug candidates that invoke the desired aspects of the natural ligand pharmacology, bypass native inhibitory mechanisms, and deliver a sustained activation signal to the disease-relevant cell types. We are backed by Atlas Venture and Lightspeed Venture Partners and are operated by a team of experts in antibody engineering, biology, computational design, and company formation.