We live in an interconnected world: the health and well-being of the environment, animals, and humans are intertwined in ways that are becoming increasingly apparent. Tackling today’s greatest challenges—whether climate change, pandemics, or drug resistance—requires an approach that recognizes these relationships. The One Health Trust (OHT), which was founded as the Center for Disease Dynamics, Economics & Policy (CDDEP) in 2010, uses research and stakeholder engagement to improve the health and well-being of our planet and its inhabitants. For more than a decade, OHT researchers have conducted vitally important work on major global health challenges, including Covid-19, antimicrobial resistance, hospital infections, tuberculosis, malaria, pandemic preparedness and response, vaccines, medical oxygen shortages, and noncommunicable diseases. OHT’s mandate includes issues related to climate change, biodiversity protection, and the effect of changing human diets on the planet. At OHT, we believe that answers to the world’s most critical questions lie between disciplines. Accordingly, our researchers employ a range of expertise—from economics, epidemiology, disease modeling, and risk analysis to clinical and veterinary medicine, geographic information systems, and statistics—to conduct actionable, policy-oriented research. OHT has offices in Washington, D.C.and Bangalore, India, with researchers based in North America, Africa, and Asia. Our projects lead to policy recommendations and scientific studies published in leading journals. We are experienced in addressing country-specific and regional issues as well as global challenges. Our research is renowned for innovative approaches to design and analysis, and we communicate our work to diverse stakeholders.