The mission of the Centre for Structural Systems Biology (CSSB) is to develop a fundamental understanding of infection mechanisms by investigating the molecular architecture of macromolecules from the host and pathogen as well as the functional interactions that trigger the infection process. Within the CSSB – a cooperation of ten partner institutions – scientists will use a novel approach which combines integrative structural biology with systems biology approaches to advance our understanding of the molecular mechanisms of some of the world’s most widespread infections. This knowledge is fundamental for the development of new therapeutic strategies to combat infectious diseases.