Established in 1966, the Research Institute for Fragrance Materials (RIFM) generates, analyzes, evaluates, and distributes data to provide a scientific basis for the safe use of fragrances. RIFM has compiled the most comprehensive, worldwide source of toxicology data, literature, and general information on fragrance and flavor raw materials. RIFM’s fragrance ingredient safety assessment program draws information from its comprehensive database of over 70,000 references and more than 135,000 human health and environmental studies. For further information about RIFM, go to rifm.org. To access all of RIFM’s peer-reviewed work, visit fragrancematerialsafetyresource.elsevier.com.