The Wisconsin Institute for Discovery is a research institute on the campus of the University of Wisconsin—Madison built to develop a new approach to science driven by unlikely collaborations and great minds from across the campus and the world. WID experiments with new ways of creating unlikely campus-wide interdisciplinary research teams that generate unexpected discoveries. Researchers at WID are dedicated to fundamental discovery, applied research, and new pathways to collaborations that will contribute to improving the health of people and the food supply in Wisconsin and the world. We seek partnerships with the Morgridge Institute for Research, the University of Wisconsin—Madison, the State of Wisconsin, and others, using a “campus crowd-sourcing” approach to produce unexpected research collaborations that push the limits of modern science. WID is located in the award-winning Discovery Building along with its partners the private, non-profit Morgridge Institute for Research and the Wisconsin Alumni Research Foundation. WID’s collaborative research community relies on grant support from a variety of sponsors. Since opening in 2010, the Institute has been awarded and administered more than $22 million in grant funding from a variety of foundations and agencies. The Institute also benefits from the state of Wisconsin’s initial investment in the Discovery Building as well as for ongoing operational support.