The St. Louis Regional STEM Learning Ecosystem (STEMSTL) is a collaborative consortium committed to equitable access to high-quality STEM learning for all students in the St. Louis metro region. With a youth-centered focus and a commitment to transparency, information sharing, data-driven decision making, and continuous improvement, the St. Louis STEM Ecosystem will advance regional STEM collaboration beyond networking and cooperation toward a common vision and agenda, shared planning and measurement, mutually reinforcing activities, and continuous communication that deepens students' engagement with STEM and prepares them to live and thrive in a globally connected, technology-driven world.