Founded in 2005 by Microsoft Research and The University of Trento and now based in Rovereto (TN), COSBI represents an almost unique research centre which exploits a comprehensive systems biology pipeline starting from the integration of experimental data with knowledge extraction and the identification of biomarker signatures, to network/pathway analysis and modeling and simulation. Based on the key drivers in the relevant scientific and business sectors, COSBI main pillars are the Development of Novel Computational Tools and their application to Systems Pharmacology and Systems Nutrition. COSBI partners with academic and non-academic research centres, pharma, food and biotech companies to promote personalized medicine and nutrition.