CRCI2NA Nantes - Angers Cancer and Immunology Research Center The CRCI²NA (Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers in french) was created in January 2022 by the INSERM, the CNRS, the University of Nantes, and the University of Angers as a result of a structuration of oncology and immuno-cancerology research that was initiated in 1979. This Center is composed of 12 research teams dedicated to the analysis of tumors as ecosystems composed of distinct cell types, linked by cooperative or competitive relationships. The overall project of the CRCI²NA is to explore the interactions and dynamic changes of tumor ecosystems during tumor progression as well as the mechanisms of dissemination in response to treatments. More specifically, the CRCI²NA teams focus on the death/survival decisions of malignant cells as well as their molecular evolution, the reactivity of immune cells and the cooperativity of stromal cells. They combine a broad spectrum of expertise, including cancer genomics and computational biology, cell and molecular biology, cell models (3D and murine), immuno-oncology and imaging. This multi-scale approach allows the identification of diagnostic and predictive tools, the deciphering of treatment resistance mechanisms and the design of innovative therapies and theranostic approaches, based on the molecular, phenotypic and radiomic specificities of each cancer. Spread over five sites, the CRCI²NA is the largest cancer research center in the Grand Ouest region.