The International Plant Nutrition Institute (IPNI) from 2007 to 2019 was a not-for-profit, science-based organization dedicated to the responsible management of plant nutrition for the benefit of the human family. IPNI had active programs in Africa, Australia/New Zealand, Brazil, China, Eastern Europe/Central Asia and Middle East, Latin America-Southern Cone, Mexico and Central America, Northern Latin America, North America (Canada and U.S.A.), South Asia, and Southeast Asia. As a global organization, IPNI had initiatives addressing the world’s growing need for food, fuel, fiber, and feed. It also addressed widespread concern for issues such as food security and the relationship of crop production to the environment and ecosystems. Through cooperation and partnering with respected institutions around the world, IPNI added its strengths to agronomic research, education, demonstrations, training, and other endeavors. Best management practices for nutrient stewardship encouraged the 4R concept of applying the right source, at the right rate, at the right time, and in the right place. The agronomic programs ended in 2019. IPNI began in 1935 as the American Potash Institute (API).