The Pan-Mass Challenge raises money for life-saving cancer research and treatment at Dana-Farber Cancer Institute through an annual bike-a-thon that crosses the Commonwealth of Massachusetts. Since its founding in 1980, the PMC has successfully melded support from committed cyclists, volunteers, corporate sponsors and individual contributors. All are essential to the PMC's goal and model: to attain maximum fundraising efficiency while increasing its annual gift. Our hope and aspiration is to provide Dana-Farber's doctors and researchers with the necessary resources to discover cures for all cancers. The 2022 gift was $69 million. Since 1980, the PMC has raised $900 million.