Concerto Biosciences examines the microbial world with unmatched experimental depth to discover breakthrough microbe-based products. We draw inspiration from microbial ecology: Microbes all around us work in concert to improve human health, enhance food quality, and boost crop yield. Designing products that recreate these capabilities requires an unprecedented understanding of how microbes behave together. Concerto unlocks this knowledge with kChip, a discovery engine that physically constructs millions of miniature, defined microbial communities simultaneously. By observing the behavior of each community, Concerto rapidly identifies the most promising microbes, prebiotics, and postbiotics for development into new products. In our first endeavor, Concerto constructed >6 million communities of skin-dwelling microbes to discover an eczema-alleviating “ensemble” of bacteria that pacifies pathogenic S. aureus. We have since initiated discovery projects in vaginal health, gut health, and agriculture. In partnership with a diverse array of biotech and biopharma companies, Concerto aims to unleash a new era of microbial research and a treasure trove of microbe-based products.