The KIOS Research and Innovation Center of Excellence (KIOS CoE) operates within the University of Cyprus. The Center was established in 2008 and was subsequently selected by the EU to advance into a Research and Innovation Center of Excellence in 2017. With collaboration with Imperial College London, KIOS has succeeded in securing funding in excess of 40 million euros for the period of 2017-2022. This is the largest and most competitive funding to be secured for research and innovation in Cyprus which will be implemented as part of the EU’s strategic Horizon 2020 program for “Spreading Excellence and Widening Participation – Teaming”. The KIOS CoE is the largest research and innovation center in Cyprus on Information and Communication Technologies (ICT) with an emphasis on monitoring, control, management and security of critical infrastructures such as electric power systems, water distribution networks, telecommunication networks, and transportation systems. The goal of the Center is to conduct outstanding interdisciplinary research and innovation and produce new knowledge and tools that can be applied to solve real-life problems. The Center collaborates with an extended network of national and international academic, industrial, and governmental organizations to assure that its research has maximal applicability and impact.