Cure EB exists to treat and cure epidermolysis bullosa, a genetic skin condition that leads to blistering and skin loss with the mildest friction. It is “Hard to say. Hell to live with” and children with the condition live in constant pain associated with the burn like wounds that occur. The intense pain and repeated damage leads to progressive disability and severe forms are life shortening due to a particularly aggressive skin cancer that develops in early adulthood. We have a particular focus on gene modifying and gene corrective strategies aimed at translation into treatments.