The NC3Rs is a UK-based scientific organisation dedicated to replacing, refining and reducing the use of animals in research and testing (the 3Rs). We collaborate with scientists and organisations from across the life sciences sector, nationally and internationally, including universities, the pharmaceutical, chemical and consumer products industries, other research funders, and regulatory authorities. We support the commitment of the scientific community to the 3Rs by funding research and early career development, supporting open innovation and the commercialisation of 3Rs technologies, and stimulating changes in policy, regulations and practice.