The Safety Pharmacology Society is a nonprofit organization that promotes knowledge, development, application, and training in safety pharmacology—a distinct scientific discipline that integrates the best practices of pharmacology, physiology and toxicology. Vision The Society will lead the global safety pharmacology community in the development and safe medical use of biologically active molecular entities. We will achieve this vision by bridging across disciplines to predict, identify, characterize, monitor, and mitigate potentially undesirable pharmacodynamic activities in nonclinical studies and guiding their translation into clinical trials and beyond, to benefit all patients. Purpose: Safety pharmacology leaders providing guidance and answers to critical questions that matter to patients, regulators, and scientists.