As part of the Duke University School of Medicine, the Duke Clinical Research Institute (DCRI) is known globally for conducting groundbreaking multinational trials, managing major national patient registries, and performing landmark research. As an academic clinical research organization, we combine the faculty expertise of practicing physicians with the full-service operational capabilities of a major CRO. We design and implement innovative clinical trials that advance the understanding of health and disease and inform efforts to improve the quality of care. Our experience stretches from phase I to phase IV and beyond, encompassing post-approval analyses and health economics. The breadth of our work in numerous therapeutic areas is matched by the depth of our knowledge, which we disseminate through high-impact publications and global meetings. Since 1996, DCRI's faculty and staff have disseminated over 17,500 peer-reviewed publications and have been cited in over 760,500 scientific articles.