Established 1959, AO Research Institute Davos (ARI) aims to: • Contribute to high quality applied preclinical research and development (exploratory and translational) focused towards clinical applications/solutions. • Investigate and improve the performance of surgical procedures, devices, and substances. • Foster a close relationship with the AO medical community, academic societies, and universities. • Provide research environment/support for AO clinicians. All AO Research Institute Davos projects are applied preclinical research or applied preclinical development projects focused towards clinical applications. Definitions (within the applied research): • Exploratory applied preclinical research is fundamental research, to solve major clinical problems over an extended timeframe (over ten years). • Translational applied preclinical research aims at developing a clinical applicable result in around five years and builds upon the fundamental applied preclinical research. This research is usually not possible without the previous fundamental applied preclinical research.