Public Health Expertise (PHE) has extensive experience in developing simulation models in various therapeutic areas and is recognised as an expert team, able to interpret and implement real-life data, clinical-trial based evidence, and clinical experts’ opinions into state-of-the-art mathematical models across all therapeutic areas. PHE project managers include former French high health authority (HAS) and pricing committee (CEPS) members. Having submitted dozens of transparency and efficiency dossiers across all major therapeutic areas, they are experts of both clinical and economic assessment processes in France. Our experiences alongside strong medical skills allow us to develop comprehensive solutions for cost-effectiveness modelling and HTA processes, including resources (evidence generation, , indirect drug comparisons, clinical value summary) and cost-effectiveness models development, planning of the market access strategy and interactions with clinical experts, payers and stakeholders.