Applied Visual Sciences, Inc. (OTCBB:APVS) has originated a breakthrough technology platform for the automated analysis of digital imagery to extract information that can lead to the detection and identification of health-threatening diseases and explosive materials that threaten personal safety and critical infrastructure security. APVS’s portfolio of technologies, and product applications, address the physiological shortcomings of human vision by providing enhanced visualization, quantification, material and tissue characterization, and automated target detection and identification capabilities. APVS’s technology can analyze digital images from any originating optical source. APVS currently holds six patents, with several additional applications under review. APVS’s two wholly owned subsidiaries have developed advanced image analysis applications employing this intellectual property for specific market segments. Guardian Technologies International, Inc. (GDTI) focuses on the development of automated target recognition software solutions for the homeland security and military marketplaces. Signature Mapping Medical Sciences, Inc. (SMMS) focuses on the development of automated medical diagnostic and decision support software solutions for radiology and laboratory/pathology applications.