The National Cancer Institute CRO Aviano (Pordenone, Italy) is a major health research center and a highly specialized hospital in the oncology sector. The Institute works to improve public health by advancing medical knowledge, providing outstanding specialty medical care to patients, and preparing tomorrow’s physicians, scientists and other health professionals in the field of oncology. It is a public, nonprofit institute operating under the authority of the Italian Health Ministry for the clinical & experimental research functions and shared in the governance by the Friuli Venezia Giulia region as for patient care