Mastelli is a historical Italian bio-pharmaceutical company with 70 years of experience in the development, production, and marketing of polynucleotides (PN) and polydeoxyribonucleotides (PDRN) for medical applications. Mastelli is the originator company of DNA fractions usage in the world. Mastelli develops and produces internally the global range of PN and PDRN-based drugs and medical devices from raw materials to the sale and distribution of finished products. Mastelli is the only company in the world that has developed over the years a wide range of proposals that integrate DNA fractions with other technologies and are therefore able to offer innovative solutions and protocols for medical applications in several therapeutic areas (aesthetic medicine, orthopedics, gynecology, dermatology, and advanced wound care).