The research of the Energy and Process Systems Engineering (EPSE) Group at ETH Zürich focuses on sustainability in energy and chemical process systems. We develop methods to advance sustainable energy and chemical process systems from the molecular to the systems scale. In our work, we combine computer-aided molecular and process design to optimize molecules and processes simultaneously. To holistically evaluate the environmental impacts of chemicals and energy systems, we develop predictive methods for Life Cycle Assessment. Our technological focus currently lies in Power-to-X & sector coupling, sustainable carbon feedstock, and carbon capture, utilization & storage.