The Lewis-Sigler Institute for Integrative Genomics (LSI) at Princeton University was established with a mandate to create innovative research programs at the interface of modern biology and the more quantitative sciences. The institute comprises a multidisciplinary group of scientists and students working at the interface of biology and the more quantitative sciences and computation. This is meant to include, among others, the fields of genomics, biophysics, computational neurobiology, systems biology, population biology and quantitative genetics, molecular evolution, computational biology, and microbial interactions.