Cardiovascular device manufacturing and sales. FDA approved closure device Biologic Vascular Closure The Femoral Introducer Sheath and Hemostasis Device (FISH™) is a new approach to vascular closure that utilizes a ribbon of extracellular matrix, known as small intestinal submucosa (SIS®), pre-mounted on a sheath introducer to serve as the closure mechanism. Closure Begins with Access FISH™ is the first device to combine access of the vessel and closure into one device. SIS® Technology The FISH™ Device utilizes SIS® (small intestinal submucosa), “a natural, extracellular matrix scaffold with three-dimensional structure and a biochemical composition that is attractive to host cell infiltration and conductive to tissue regeneration.”