Plexxikon, a member of the Daiichi Sankyo Group, is a leader in the discovery and development of novel, small molecule pharmaceuticals. The company has utilized its proprietary discovery platform to successfully develop a portfolio of competitively differentiated clinical and preclinical stage programs in a number of therapeutic areas and disease indications. Plexxikon’s platform enables the design of highly selective and targeted medicines, supporting the company’s broader strategy to develop personalized medicines. In 2005, Plexxikon scientists discovered ZELBORAF® (vemurafenib) tablets, formerly known as PLX4032, and initiated the first clinical trial in 2006. Together with its partner Roche, Plexxikon co-developed this mutation-specific medicine, in less than five years. A companion diagnostic used to determine ZELBORAF treatment eligibility was approved at the same time. ZELBORAF has been approved in over 40 countries worldwide. Plexxikon's demonstrated capability in discovery and early development, as well as its diverse pipeline, uniquely positions the company to develop multiple commercial franchises for different therapeutic indications, and create significant value for Plexxikon and its collaborators. Plexxikon's novel discovery approach, combined with an experienced management and scientific team, a broad network of scientific and clinical experts, and partnerships that support later stage development, have been key drivers of the company's success since it began operations in 2001.