The Centre for Infectious Disease Research in Zambia (CIDRZ) is an independent nonprofit Zambian company, registered as a nongovernmental organization that is committed to answering key research questions relevant to Zambia and the region. It supports the financial, and technical local ownership of high quality, complementary and integrated healthcare services within the Zambian public health system, and facilitates clinical, research and professional development training. Through close and on-going collaboration with the Government of the Republic of Zambia, Ministry of Health and other line Ministries, and by partnering with multiple leading local and international universities, CIDRZ ensures that the latest research methodologies are used to answer locally relevant questions to improve healthcare delivery. CIDRZ runs several fellowship programmes aimed at building capacity of Zambian researchers to participate in finding solutions to health challenges. Achieving HIV Epidemic Control in Zambia – ACHIEVE. Our alliances with various prominent, local and international universities, guarantees that cutting-edge research methodologies are applied to address relevant grass root enquiries which advance deliverables on healthcare. Pioneering implementation science, qualitative research, capacity building projects, clinical trials and health systems strengthening, has enabled CIDRZ to generate accurate analysis to inform policy which in turn fortifies local and international healthcare.