The McDonnell Genome Institute (MGI), as part of WashU Medicine in St. Louis, aims to improve the human condition by producing, studying, and interpreting high-quality omics data that drives translational biological discoveries. MGI is a world leader in genomics with a rich history of major collaborations, managing large, complex projects, and disseminating data through well-established sharing and outreach pipelines. Our work is particularly unique due to the breadth of resources we offer in one location, from multiple DNA sequencing technologies to genome engineering and CRISPR screening using high-content cellular imaging to mass spectrometry for proteomic and metabolomic assays. We also provide connectivity between medical records and multi-omic data from patient samples.