T.E.I. of Larissa was established as a tertiary education institution in 1983 (under Act 1404/83), along with all Greek T.E.I.s which replaced the existent Higher Technical & Vocational Centres.
In 2001 (under Act 2916/2001) all Technological Educational Institutions were established as Higher Education institutions along with the universities, in compliance with the Bolognia declaration. According to Act 3549/2007 Higher Education in Greece consists of two parallel sections:
* The university section comprising all Universities, Polytechnics and the Athens School of Fine Arts
* The technological section comprising all Technological Educational Institutions and the Higher School of Pedagogy & Technological Education