After Shapur the First, the Sassanid King, conquered the Roman Emperor, commanded the Roman POWs to build a new town in a location that was 18 Kilometers South-East the present Dezful city. That town was called Gondi Shapur (meaning the city of Shapur), was a focal point for scientists and acedemics. In the 5th century A.D., a university and a hospital were established in Gondi Shapur that were functional up to 3rd century A.H.
After 15 centuries, in 1955 (1334 A. H.), the first nucleus of rebirth of Gondi Shapur University in the modern era was set by establishment of a college of Agriculture in Ahvaz. This college grew up to be one of the most important institutions of its kind in the country. Other colleges and schools were established thereafter, and the university, now named Jundi Shapur University, expanded rapidly. In 1969 the School of Agriculture was recognised as the best school of its kind in Middle East countries.
In 1982 the university was renamed after martyrdom of Dr Chamran, the date commander in chief of a group of a guerrilla battalion, that was based in Jundi Shapur University campus in the war between Iraq and Iran. The university was closed in those days due to war conditions in the area.