MPI Cognition was established to reduce the global burden of dementia—to prevent cognitive decline in all who are at risk, and reverse the process in those who are symptomatic, especially those with early symptoms. MPI Cognition provides advanced medical information and algorithms that assist individuals and practitioners to prevent and reverse cognitive decline. In a disease that was deemed untreatable, we were the first to describe success (Bredesen, Aging 2014), and this has continued, using a personalized programmatic approach rather than a single ineffective pill.