The Center for Managing Chronic Disease conducts research and demonstration that aim to build the capacity of individuals, families, communities, and health care systems to effectively prevent and manage chronic disease. It is a worldwide collaboration of researchers and interventionists who focus their work on management of heart disease, diabetes, respiratory disease, breast cancer, allergy, Alzheimer's disease, and factors associated with obesity. The Center pursues its mission nationally and internationally collaborating with colleagues who are doing innovative work related to the social, behavioral, environmental and clinical aspects of chronic disease control. The Center fosters these collaborations to create new approaches to disease management and also adapts projects and programs successful in one area for use in another. We disseminate successful interventions so they reach the largest number of people, in particular, low-income families, minorities, children, older adults and women. While no one intervention is likely to change the picture of chronic disease, the Center believes that careful research of an array of solutions for individuals, families, clinicians, and systems will evolve into what collectively can achieve optimum disease management and control.